Pharmacokinetic Properties of Sulfadoxine-Pyrimethamine in Pregnant Women
نویسندگان
چکیده
منابع مشابه
Pharmacokinetic properties of sulfadoxine-pyrimethamine in pregnant women.
To determine the pharmacokinetic disposition of sulfadoxine (SDOX) and pyrimethamine (PYR) when administered as intermittent presumptive treatment during pregnancy (IPTp) for malaria, 30 Papua New Guinean women in the second or third trimester of pregnancy and 30 age-matched nonpregnant women were given a single dose of 1,500 mg of SDOX plus 75 mg of pyrimethamine PYR. Blood was taken at baseli...
متن کاملThe use of intermittent preventive treatment with sulfadoxine-pyrimethamine for preventing malaria in pregnant women.
When a woman is pregnant, especially for the first and second times, she is susceptible to more frequent and severe malaria infections than when she was not pregnant. These infections are associated with maternal anemia, premature deliveries, and low birth weight infants. In areas where malaria is endemic, strategies to control malaria during pregnancy include preventive measures, such as the u...
متن کاملHigh prevalence of sulfadoxine/pyrimethamine-resistant alleles of Plasmodium falciparum isolates in pregnant women at the time of introduction of intermittent preventive treatment with sulfadoxine/pyrimethamine in Gabon.
OBJECTIVES The frequency of dhfr and dhps point mutations was assessed in Plasmodium falciparum isolates from pregnant women in Libreville. METHODS PCR-restriction fragment length polymorphism of polymorphic codons of the dhfr gene (51, 59 and 108) and the dhps gene (436, 437 and 540) was performed in matched peripheral and placental blood samples. RESULTS The proportion of multiple mutatio...
متن کاملQuality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of Ghana
The use of sulfadoxine-pyrimethamine (SP) as an intermittent preventive treatment (IPT) against malaria during pregnancy has become a policy in most sub-Sahara African countries and crucially depends on the efficacy of SP. This study sets out to evaluate the effectiveness of the SP given to the pregnant women in some selected health facilities in the Central Region of Ghana to prevent maternal ...
متن کاملA randomized, controlled trial of intermittent preventive treatment with sulfadoxine-pyrimethamine, amodiaquine, or the combination in pregnant women in Ghana.
BACKGROUND The use of sulfadoxine-pyrimethamine (SP) for intermittent preventive treatment in pregnancy (IPTp) is threatened by the spread of resistance to SP. Therefore, we studied the efficacy, safety, and tolerance of amodiaquine (AQ) or the combination of AQ and SP (SPAQ) as possible alternative treatments. METHODS The study was performed in Ghana from June 2004 through February 2007. Wom...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2009
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00335-09